Utility of an immunoglobulin gene rearrangement assay based on multiplex PCR in detecting bone marrow involvement in B-cell non-Hodgkin lymphoma
نویسندگان
چکیده
Abbreviations: DLBL, diffuse large B-cell lymphoma; FL, follicular lymphoma; MALT, MALT type lymphoma; MCL, mantle cell lymphoma; NMZL, nodal marginal zone B-cell lymphoma; PCR, polymerase chain reaction; SLL, small lymphocytic lymphoma; WHO, World Health Organization. sentation of hairy cell leukemia: a case series of four clinically unsuspected cases. Indian J Hematol Blood Transfus 2014;30(Suppl 1):413-7. 4. Bethel KJ, Sharpe RW. Pathology of hairy-cell leukaemia. Best Pract Res Clin Haematol 2003;16:15-31. 5. Del Giudice I, Matutes E, Morilla R, et al. The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica 2004;89:303-8. 6. Bamanikar S, Kumar H, Verma A, Buch A. Hairy cell leukemia: a case report. JMS 2012;2:200-3. 7. Grever MR. How I treat hairy cell leukemia. Blood 2010;115: 21-8. 8. Robak T, Matutes E, Catovsky D, Zinzani PL, Buske C; ESMO Guidelines Committee. Hairy cell leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2015;26(Suppl 5):v100-7.
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Analysis of Immunoglobulin and T Cell Receptor Gene Rearrangement in the Bone Marrow of Lymphoid Neoplasia Using BIOMED-2 Multiplex Polymerase Chain Reaction
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In B-cell non-Hodgkin's lymphoma (NHL), as in other B-cell malignancies, clonal rearrangement of the third complementarity determining region (CDR III) of the immunoglobulin heavy chain gene (IgH) provides a useful marker for the detection of minimal residual disease (MRD) after treatment. To determine the clinical utility of IgH polymerase chain reaction (PCR), we analyzed peripheral blood (PB...
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Rearrangement of the immunoglobulin heavy chain (IgH) gene has been used as a marker of lineage and clonality in the diagnosis of B lymphoproliferative disorders. A number of PCR-based techniques have been developed to overcome the disadvantages of Southern blotting, the standard technique in detecting IgH gene rearrangement. Using an established seminested PCR technique with consensus primers ...
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REFERENCES 1. Lossos IS. Molecular pathogenesis of diffuse large B-cell lymphoma. J Clin Oncol 2005;23:6351-7. 2. Kang YH, Park CJ, Seo EJ, et al. Polymerase chain reaction-based diagnosis of bone marrow involvement in 170 cases of non-Hodgkin lymphoma. Cancer 2002;94:3073-82. 3. Sandberg Y, van Gastel-Mol EJ, Verhaaf B, Lam KH, van Dongen JJ, Langerak AW. BIOMED-2 multiplex immunoglobulin/T-ce...
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